Stoichiometry-dependent gating and structural pharmacology of cardiac GIRK1/4 channels
Liang Wang, Takeharu Kawano, Ana Santa‐Cruz, Nousheen Parvaiz, Andrew Zorn, Yongcheng Lu, Mehreen Zaka, Nihal Aly, James T. Pentikis, Evangelos Dadiotis, Kim W. Chan, Meng Cui, Leigh Daniel Plant, Diomedes E. Logothetis, Georgios Skiniotis
The paper reports structures of GIRK1/4 channels with different stoichiometries and shows how subunit composition affects ligand binding and pharmacology.
bioRxiv · Oct 7, 2026 · PreprintMolecular Biology