Evaluation of Candidate ''Kill or Cure'' Strategies to Treat MFN2-related Lipodystrophy
Ineke H. N. Luijten, Xiong Weng, Ula Kibildyte, Jana Buchan, Ami Onishi, Jake Peter Mann, Eleanor J. McKay, David B. Savage, Robert K. Semple
This study evaluates 'kill or cure' strategies for MFN2-related lipodystrophy, finding that ethanol mildly worsens the condition in mice while rapamycin is well-tolerated but lacks efficacy in targeting Mfn2R707W cells.
Molecular Medicine · Aug 4, 2025Peer-reviewedPhysiology