Ineke H. N. Luijten

This study evaluates 'kill or cure' strategies for MFN2-related lipodystrophy, finding that ethanol mildly worsens the condition in mice while rapamycin is well-tolerated but lacks efficacy in targeting Mfn2R707W cells.

This study investigates whether increased energy expenditure in Pik3r1-related insulin resistance is due to Ucp1-mediated thermogenesis, finding no evidence for this mechanism.

This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.