A mixture of plant polyphenols unexpectedly aggravates liver metastasis of colorectal cancer in mice
Merve Erdem, Johanna Roth, Jana Knobloch, Jochen Nolting, Hannes Hatten, Eray Şahin, Felix Schön, Sandra Halbfeld, Nicole Simone Treichel, Thomas Clavel, Roman David Bülow, Christian Liedtke, Thorsten Cramer
This study shows that a plant polyphenol mixture accelerates liver metastasis in mice, suggesting potential immunomodulatory effects that require validation in immunocompetent models.
bioRxiv · Feb 17, 2026 · PreprintCancer Biology