Thorsten Cramer

Tumors accumulate expanded GATA3-dependent tissue Tregs

The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

A mixture of plant polyphenols unexpectedly aggravates liver metastasis of colorectal cancer in mice

This study shows that a plant polyphenol mixture accelerates liver metastasis in mice, suggesting potential immunomodulatory effects that require validation in immunocompetent models.

Broad diversity of human gut bacteria accessible via a traceable strain deposition system

The paper establishes a publicly available collection of 340 human gut bacterial strains, including 29 newly described species, and identifies plasmids and megaplasmids within these isolates.

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

The paper develops patient-specific signaling pathway models using microfluidic screenings and logic-based modeling to predict personalized cancer therapies.

Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer

The paper uses a kinetic model of central carbon metabolism to predict metabolic reprogramming in liver cancer and validates findings through experiments.

Chromosomal rearrangements are commonly post-transcriptionally attenuated in cancer

The paper analyzes proteogenomic data to show that chromosomal rearrangements often reduce protein abundance post-transcriptionally, particularly in protein complexes, and identifies regulatory interactions linked to drug resistance.