Metabolic commitment to human motor neurons is characterized by mitochondrial depletion and pyruvate rewiring
Rubén Torregrosa‐Muñumer, Jeremi J Turkia, Danil Spirin, Jouni Kvist, Jonna Saarimäki‐Vire, Suleva Povea-Cabello, Rumeysa Ermiş, Jana Pennonen, Emilia Kuuluvainen, Timo Otonkoski, Ville Hietakangas, Thomas G. McWilliams, Erika Fernández‐Vizarra, Pekka Katajisto, Henna Tyynismaa
The paper characterizes metabolic changes in human motor neuron differentiation, showing mitochondrial depletion and a shift in pyruvate metabolism.
bioRxiv · Oct 6, 2026 · PreprintCell Biology