Tomi Taira

Early life stress leads to an aberrant spread of neuronal avalanches in the prefrontal-amygdala network in males but not females

This study shows that early life stress increases neuronal avalanche spread in the prefrontal-amygdala network in male rats but not females, indicating sex-dependent effects on brain network dynamics.

Different developmental trajectories of critical dynamics in prefrontal cortex-amygdala circuitry

The paper examines developmental changes in neuronal avalanches in the mPFC-BLA circuit of rats, finding distinct critical dynamics in each region.

Motor learning is regulated by GDNF levels in postnatal cerebellar Purkinje cells

This study shows that increasing GDNF in postnatal Purkinje cells enhances motor learning in mice, with findings relevant to human motor skill differences.

Spontaneous activity of striatal projection neurons supports maturation of striatal inputs to substantia nigra dopaminergic neurons

The paper shows that spontaneous activity in striatal projection neurons is essential for the maturation and stabilization of their long-range projections to dopaminergic neurons.

Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants

This study shows that TrkB activation in PV+ interneurons is essential for antidepressant-induced behavioral flexibility and synaptic plasticity in spatial and fear memory.

Transient developmental increase in cortical projections to amygdala GABAergic neurons contribute to circuit dysfunction following early life stress

This study investigates how early life stress affects prefrontal-amygdala connectivity in rats, finding transient increases in GABAergic inhibition and reduced network synchronization in males but not females.

Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinction

The paper uses optogenetics to activate TrkB receptors in the ventral hippocampus, enhancing plasticity and improving fear extinction in mice.

CHCHD10 OR CHCHD2 ARE NOT REQUIRED FOR HUMAN MOTOR NEURON DIFFERENTIATION IN VITRO BUT MODIFY SYNAPTIC TRANSCRIPTOMES

Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity

The paper shows that optogenetic activation of TrkB receptors in PV interneurons increases cortical plasticity by altering neuronal excitability and gene expression.

Tropomyosin Tpm3.1 is required to maintain the structure and function of the axon initial segment

This study identifies Tpm3.1 as essential for maintaining AIS structure and function by stabilizing actin filaments in the axon initial segment.

Maturation of Neuronal Activity in Caudalized Human Brain Organoids

This study describes a protocol to generate hindbrain-like human brain organoids with mature, functional neurons and reports their response to Zika virus and anticonvulsants.

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

This study shows that isoflurane anesthesia produces antidepressant-like effects in rodents by activating TrkB signaling and related molecular pathways.