Pekka Katajisto

Nutrient-responsive midgut turnover is spatially controlled by serotonin signaling

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

mTORC1-dependent control of Hedgehog signaling mediates nutrient-responsive licensing of intestinal stem cell differentiation

This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.

Metabolic commitment to human motor neurons is characterized by mitochondrial depletion and pyruvate rewiring

The paper characterizes metabolic changes in human motor neuron differentiation, showing mitochondrial depletion and a shift in pyruvate metabolism.

Loss of mitochondrial co-chaperone GRPEL2 protects mice from age- and diet-induced obesity

This study shows that loss of GRPEL2 in mice protects against age- and diet-induced obesity and improves metabolic health without affecting mitochondrial protein import.

Alanine catabolism of Paneth cells maintains intestinal stem cell function during dietary restriction

This study shows that Paneth cells use alanine catabolism to produce lactate, which supports intestinal stem cell function during dietary restriction.

High-resolution integrative analysis allows characterization and spatial annotation of normal and cancer-associated colon fibroblasts

This study characterizes and spatially annotates normal and cancer-associated colon fibroblasts using single-cell RNA-sequencing and spatial transcriptomics.

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin

The paper shows that mesenchymal Asporin mediates fetal-like reprogramming in regenerating intestinal epithelium by modulating Tgfβ signaling through CD44.

Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer

This study shows LAMA5 is essential for luminal breast cancer initiation and progression, with Fgf signaling playing a key role in its effects.

Ribosome-binding protein 1, RRBP1, maintains peroxisomal biogenesis

This study identifies RRBP1 as a novel peroxisome biogenesis factor in human cells, showing it promotes peroxisome formation and stabilizes peroxisomal proteins.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Functional, metabolic and transcriptional maturation of stem cell derived beta cells

This study generates and benchmarks functionally mature stem cell-derived islets, showing they closely resemble primary adult islets in transcriptional and functional properties.

Polycomb Repressive Complex 2-controlled Essrg regulates intestinal Microfold cell differentiation.

The paper identifies Essrg as a necessary factor for Sox8-mediated M cell differentiation, regulated by PRC2 during intestinal M cell development.