Ville Hietakangas

Protecting host mitochondria with vitamin B3 preserves bioenergetics and thermogenesis during antibiotic treatment

This study shows that vitamin B3 supplementation protects mitochondria from antibiotic-induced damage, preserving bioenergetics and thermogenesis in Drosophila and human cells.

Nutrient-responsive midgut turnover is spatially controlled by serotonin signaling

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

mTORC1-dependent control of Hedgehog signaling mediates nutrient-responsive licensing of intestinal stem cell differentiation

This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.

Evolutionary conservation and divergence of regional fructose-responsive gene regulation in the intestine

This study examines how fructose-responsive gene regulation varies across intestinal regions in mice and fruit flies, finding conserved pathways and divergent metabolic responses.

Metabolic commitment to human motor neurons is characterized by mitochondrial depletion and pyruvate rewiring

The paper characterizes metabolic changes in human motor neuron differentiation, showing mitochondrial depletion and a shift in pyruvate metabolism.

Spalt-related is an integrated stress response-activated inhibitor of mTORC1-mediated growth

This study identifies Spalt-related (Salr) as a negative regulator of growth and lipid storage, activated through the integrated stress response and converging with FoxO to promote catabolism during nutrient stress.

Apical actin filament turnover mediated by cyclase-associated protein is required for organization of non-centrosomal microtubules in epithelium

This study shows that CAP-mediated apical actin turnover is necessary for proper non-centrosomal microtubule organization in Drosophila epithelial cells, affecting nuclear positioning and cargo transport.

Alanine catabolism of Paneth cells maintains intestinal stem cell function during dietary restriction

This study shows that Paneth cells use alanine catabolism to produce lactate, which supports intestinal stem cell function during dietary restriction.

Metabolic control of enteroendocrine cell fate through a redox state sensor CtBP

This study identifies CtBP as a redox state sensor that controls enteroendocrine cell fate in Drosophila by integrating metabolic signals with transcriptional regulation.

MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism

This study shows MLX phosphorylation is required for ChREBP-MLX heterotetramer formation on ChoREs, regulating carbohydrate and lipid metabolism.

Functional, metabolic and transcriptional maturation of stem cell derived beta cells

This study generates and benchmarks functionally mature stem cell-derived islets, showing they closely resemble primary adult islets in transcriptional and functional properties.