Svetlana M. Molchanova

Loss of the MeCP2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity.

This study shows that losing the MeCP2 gene in parvalbumin interneurons reduces inhibitory signaling in the amygdala and disrupts functional connectivity with the hippocampus and prefrontal cortex.

Spontaneous activity of striatal projection neurons supports maturation of striatal inputs to substantia nigra dopaminergic neurons

The paper shows that spontaneous activity in striatal projection neurons is essential for the maturation and stabilization of their long-range projections to dopaminergic neurons.

Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of amidbrain GABAergic neuron subtype with characteristics of REM sleep regulatory neurons

The paper identifies a transcription factor network involving Gata2, Nkx2-2, and Skor2 that regulates the development of midbrain GABAergic neurons associated with REM sleep regulation.

CHCHD10 OR CHCHD2 ARE NOT REQUIRED FOR HUMAN MOTOR NEURON DIFFERENTIATION IN VITRO BUT MODIFY SYNAPTIC TRANSCRIPTOMES

Maturation of Neuronal Activity in Caudalized Human Brain Organoids

This study describes a protocol to generate hindbrain-like human brain organoids with mature, functional neurons and reports their response to Zika virus and anticonvulsants.