Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy
Nguyen‐Vi Mohamed, Julien Sirois, Janani Ramamurthy, Meghna Mathur, Paula Lépine, Éric Deneault, Gilles Maussion, Michaël Nicouleau, Carol X.‐Q. Chen, Narges Abdian, Vincent Soubannier, Eddie Cai, Harris Nami, Rhalena A. Thomas, Dingke Wen, , Thomas M. Durcan
This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.
Brain Communications · Sep 23, 2021Peer-reviewedNeuroscience