Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M. Piers, James M. Staddon, Stephen J. Neame, John Hardy, Jennifer M. Pocock
The paper shows that the R47H TREM2 variant impairs microglial signaling and inflammasome activation, potentially contributing to Alzheimer's disease progression.
Scientific Reports · Jun 25, 2021Peer-reviewedNeuroscience