Author

Katharina Cosker

UCL Queen Square Institute of NeurologyORCID 0009-0009-7766-5469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Anna MallachiD· 2 shared Benjamin J. O’CallaghaniD· 2 shared Darija ŠoltićiD· 2 shared Hannah J Lucas-ClarkeiD· 2 shared Hélène Plun‐FavreauiD· 2 shared James R. EvansiD· 2 shared Jennifer M. PocockiD· 2 shared John HardyiD· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Anna MallachORCID

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4 papers

Recent·Most cited

NeuroscienceAutophagy ReportsPeer-reviewedJun 12, 2026

Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons

Benjamin J. O’Callaghan, Daniela Melandri, Darija Šoltić…·Hélène Plun‐Favreau

This study shows that glucose levels in neuronal culture media affect PINK1-dependent mitophagy in human iNeurons, with BrainPhys medium reducing mitophagy compared to N2B27.

1 citation

humanbulk RNA-seq

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NeurosciencebioRxivPreprintOct 13, 2025

The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis

Laura Mahoney‐Sanchez, Hannah J Lucas-Clarke, Alexis Penverne…·Sonia Gandhi

This study shows that the SNCA A53T mutation increases vulnerability to ferroptosis in neurons and microglia, suggesting 15-LO inhibition as a potential therapeutic target for Parkinson's disease.

1 citation

humanproteomics

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NeuroscienceScientific ReportsPeer-reviewedJun 25, 2021

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

Katharina Cosker, Anna Mallach, Janhavi Limaye…·Jennifer M. Pocock

The paper shows that the R47H TREM2 variant impairs microglial signaling and inflammasome activation, potentially contributing to Alzheimer's disease progression.

55 citationstop 5%

humanATAC-seq

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NeuroscienceThe FASEB JournalPeer-reviewedDec 23, 2019

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC--derived microglia

Thomas M. Piers, Katharina Cosker, Anna Mallach…·Jennifer M. Pocock

This study shows that TREM2 loss-of-function variants in human iPSC-derived microglia impair metabolic switching and PPARγ/p38MAPK signaling, affecting β-Amyloid phagocytosis.

135 citationstop 2%

humanbulk RNA-seq

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