Author

Stephen J. Neame

Eisai (United Kingdom)ORCID 0000-0002-6951-032XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

James M. StaddoniD· 2 shared Aleksandra Szykowska· 1 shared Alex N. BullockiD· 1 shared Anna MallachiD· 1 shared Annelies QuaegebeuriD· 1 shared Ben Powney· 1 shared Charlotta PregeriD· 1 shared David KlenermaniD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

James M. StaddonORCID

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3 papers

Recent·Most cited

Super-resolution microscopy of nanoscopic alpha-synuclein aggregates in brain samples indicates a subset of cells have disrupted protein homeostasis prior to Lewy body formation in Parkinson's disease

Emre Fertan, John S. H. Danial, Stephen J. Neame, Jeff Y. L. Lam, Matthew W. Cotton, Melanie Burke, Zengjie Xia, Yunzhao Wu, Ben Powney, Yoichi Imaizumi, Annelies Quaegebeur, Georg Meisl, James M. Staddon, David Klenerman

The paper uses super-resolution microscopy and SIMOA to analyze alpha-synuclein aggregates in Parkinson's disease brain samples and mouse models, finding larger aggregates in PD samples and differences based on extraction methods.

bioRxiv · Sep 16, 2025 · PreprintNeuroscience

Selection and structural characterisation of anti-TREM2 scFvs that reduce levels of shed ectodomain

Aleksandra Szykowska, Yu Chen, Thomas B. Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M. M. Mukhopadhyay, Edvard Wigren, Stephen J. Neame, S. Gräslund, Helena Persson, Peter J. Atkinson, Elena Di Daniel, Emma Mead, John C. K. Wang, , Alex N. Bullock

The paper identifies and characterizes anti-TREM2 scFv antibodies that inhibit soluble TREM2 production.

Structure · Jul 6, 2021Peer-reviewedMolecular Biology

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M. Piers, James M. Staddon, Stephen J. Neame, John Hardy, Jennifer M. Pocock

The paper shows that the R47H TREM2 variant impairs microglial signaling and inflammasome activation, potentially contributing to Alzheimer's disease progression.

Scientific Reports · Jun 25, 2021Peer-reviewedNeuroscience