Author

James M. Staddon

Eisai (United Kingdom)ORCID 0000-0003-2422-3674Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Stephen J. NeameiD· 2 shared Alison S. Walker· 1 shared Amy R. HicksiD· 1 shared Anna MallachiD· 1 shared Annelies QuaegebeuriD· 1 shared Ben Powney· 1 shared Bianca Ramazio· 1 shared Christin LuftiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Stephen J. NeameORCID

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Author profile →

3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 16, 2025

Super-resolution microscopy of nanoscopic alpha-synuclein aggregates in brain samples indicates a subset of cells have disrupted protein homeostasis prior to Lewy body formation in Parkinson's disease

Emre Fertan, John S. H. Danial, Stephen J. Neame…·David Klenerman

The paper uses super-resolution microscopy and SIMOA to analyze alpha-synuclein aggregates in Parkinson's disease brain samples and mouse models, finding larger aggregates in PD samples and differences based on extraction methods.

DOI 10.1101/2025.09.16.676632

humanmouse

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NeuroscienceBiochemical JournalPeer-reviewedOct 27, 2021

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

Eliona Tsefou, Alison S. Walker, Emily H. Clark…·Robin Ketteler

The paper investigates USP30 inhibition's role in enhancing Parkin-mediated mitophagy using pharmacological and genetic approaches in cellular models.

60 citationstop 5%

humanexperimental assay

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NeuroscienceScientific ReportsPeer-reviewedJun 25, 2021

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

Katharina Cosker, Anna Mallach, Janhavi Limaye…·Jennifer M. Pocock

The paper shows that the R47H TREM2 variant impairs microglial signaling and inflammasome activation, potentially contributing to Alzheimer's disease progression.

55 citationstop 5%

humanATAC-seq

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