Anna Mallach

The paper examines how proximity to tangle-bearing neurons affects transcriptional states in human entorhinal cortex cells, finding that nearby neurons and glia show distinct molecular signatures related to disease.

The paper develops a spatial averaging framework to analyze glial subcellular specialization in spatial transcriptomics data from mouse and human brain tissue, revealing differential transcriptomic responses between glial soma and processes in health and disease.

The paper identifies intrinsic molecular features of calbindin-expressing neurons in the entorhinal cortex that contribute to their vulnerability in Alzheimer's disease and suggests potential therapeutic targets.

The paper reconstructs the Alzheimer's disease neurodegenerative cascade in human L2/3 excitatory neurons using single-nucleus RNA sequencing data from multiple datasets.

This study compares two high-resolution spatial transcriptomics platforms in an AD mouse model to characterize the amyloid plaque cell niche and its cellular responses.

The paper examines gene expression changes in microglia from LRRK2-WT and G2019S knock-in mice treated with zymosan and MLi-2, identifying differential expression patterns and potential PD-related pathways.

The paper examines how TREM2 variants affect microglial exosomal proteomes and their functional impact on neurons.

The paper shows that the R47H TREM2 variant impairs microglial signaling and inflammasome activation, potentially contributing to Alzheimer's disease progression.

This study investigates how TREM2 influences microglial anti-inflammatory responses and shows that reduced TREM2 expression impairs anti-inflammatory gene expression and STAT6 levels.

This study shows that TREM2 loss-of-function variants in human iPSC-derived microglia impair metabolic switching and PPARγ/p38MAPK signaling, affecting β-Amyloid phagocytosis.