The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A
Yomna Gohar, Eirini Kalogerakou, Matthias Akyel, Priya Kumar, Margarita Darna, Simon Hendrik Stitzinger, Jannis Gottwald, Konstantina Kaplani, Claudio Piazzoni, Manyu Du, Andreas Janshoff, Ibrahim I. Cissé, Eugenio F. Fornasiero, Paolo Milani, Argyris Papantonis, , Carmelo Ferrai
This study shows that nanotopography regulates pluripotency in mESCs by altering chromatin state through the mechanosensitive demethylase KDM3A.
bioRxiv · Feb 13, 2026 · PreprintMolecular Biology