Manyu Du

This study uses a chemical method to create controlled chromosomal interactions in yeast to assess Hi-C's quantitative properties, finding it sensitive, unbiased, and linear.

This study shows that nanotopography regulates pluripotency in mESCs by altering chromatin state through the mechanosensitive demethylase KDM3A.

The paper introduces CICI, a method to selectively perturb chromosomal interactions in yeast, showing its ability to alter genome functions like DNA repair.