Polyfunctional IL-21+ IFNg+ T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy
Nicole Huang, Jessica Ortega, Kyleigh Kimbrell, Joah Lee, Lauren N Scott, Esther Peluso, Sarah Wang, Ellie Y. Kao, Kristy Kim, Jarod Olay, Joshua Nguyen, Zoe Quandt, Trevor E. Angell, Maureen A. Su, Melissa G. Lechner
This paper identifies polyfunctional IL-21+ IFNγ+ T follicular helper cells as drivers of ICI-induced diabetes and shows JAK inhibitors can prevent this autoimmune condition.
JCI Insight · Jul 7, 2025Peer-reviewedImmunology