Author

Melissa G. Lechner

University of California, Los AngelesORCID 0000-0002-4744-6566Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Esther PelusoiD· 2 shared Jessica OrtegaiD· 2 shared Maureen A. SuiD· 2 shared Ashlyn A. BuzzelliiD· 1 shared Caitlyn L. H. Pham· 1 shared Christian G. BustillosiD· 1 shared Christina Reh· 1 shared David Sailer· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Esther PelusoORCID

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2 papers

Recent·Most cited

UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes

Ho-Chung Chen, Madison F. Bang, Hsing‐Hui Wang, Karl B. Shpargel, Lisa A. Kohn, David Sailer, S.C. Zhang, Ethan C. McCarthy, Maryamsadat Seyedsadr, Satchel Stevens, Caitlyn L. H. Pham, Zikang Zhou, Xihui Yin, Nicole M. Wilkinson, Esther Peluso, , Maureen A. Su

This study identifies UTX's role in regulating progenitor CD8+ T cell fate in T1D by interacting with TCF1 and STAT3, showing its importance in autoimmune diabetes progression.

Journal of Clinical Investigation · Dec 16, 2025Peer-reviewedImmunology

Polyfunctional IL-21+ IFNg+ T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy

Nicole Huang, Jessica Ortega, Kyleigh Kimbrell, Joah Lee, Lauren N Scott, Esther Peluso, Sarah Wang, Ellie Y. Kao, Kristy Kim, Jarod Olay, Joshua Nguyen, Zoe Quandt, Trevor E. Angell, Maureen A. Su, Melissa G. Lechner

This paper identifies polyfunctional IL-21+ IFNγ+ T follicular helper cells as drivers of ICI-induced diabetes and shows JAK inhibitors can prevent this autoimmune condition.

JCI Insight · Jul 7, 2025Peer-reviewedImmunology