A Mammalian Genomic Signature Shaped by Single Nucleotide Variants Regulates Transcriptome Integrity and Diversity
Jian Yang, Samuel Sunday Ogunsola, Jason Wong, Aydan Wang, Roby Joehanes, Daniel A Levy, Shalini Sharma, Chunyu Liu, Jiuyong Xie
The paper identifies a genomic signature, G-tract-AG motifs, that regulates transcriptome integrity and diversity through repression of AG usage and SNV-induced splicing activation.
Genome biology · Apr 29, 2026Peer-reviewedGenetics