Author

Jian Yang

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetics· 3 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:database / resource· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant effect prediction· 2

Frequent Co-Authors

Chunyu LiuiD· 2 shared Jiuyong XieiD· 2 shared Samuel Sunday OgunsolaiD· 2 shared Alexander Gusev· 1 shared Alkes L. Price· 1 shared Aydan Wang· 1 shared Benjamin M Neale· 1 shared Bjarni J. Vilhjálmsson· 1 shared

Activity by Year

2016-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenetics

Chunyu LiuORCID

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Author profile →

5 papers

Recent·Most cited

Genetic regulation of circulating metabolome in cattle

Jun Teng, Houcheng Li, Jian Yang, Jingsheng Lu, Chongwei Duan, Zhujun Chen, Xinyi Zhang, Xiuxin Zhao, Fen Pei, Xiaoping Wu, Pengju Zhao, Haihan Zhang, Hongding Gao, Lewei Guo, Dan Wang, , Xiao Wang

The paper presents a cattle metabolome atlas linking genetic variants to metabolites and traits, revealing colocalization with eQTL and causal gene-metabolite-trait networks.

bioRxiv · Sep 11, 2026 · PreprintGenetics

A Mammalian Genomic Signature Shaped by Single Nucleotide Variants Regulates Transcriptome Integrity and Diversity

Jian Yang, Samuel Sunday Ogunsola, Jason Wong, Aydan Wang, Roby Joehanes, Daniel A Levy, Shalini Sharma, Chunyu Liu, Jiuyong Xie

The paper identifies a genomic signature, G-tract-AG motifs, that regulates transcriptome integrity and diversity through repression of AG usage and SNV-induced splicing activation.

Genome biology · Apr 29, 2026Peer-reviewedGenetics

An oxytocin-gated circuit from the hypothalamus silences olfactory tubercle neurons to drive prosocial grooming

YanBiao Zhong, Jian Yang, Yize Qi, Lulu Guo, Haiping Wang, Ding Wang, Xinhan Lin, Maoyuan Wang, Haishui Shi, Xinyu Nan, Haixuan Xu, Guanqing Li, Dawei Wang, Minghong Ma, Jian Mao, , Yun Feng Zhang

The paper identifies an oxytocinergic circuit from the paraventricular hypothalamus to the medial olfactory tubercle that drives prosocial grooming in mice by inhibiting mOT neurons via OXTR and GIRK channels.

bioRxiv · Mar 28, 2026 · PreprintNeuroscience

Specificity of Aberrant Exons in a Saturated Background of Differentially Expressed Exons

Urmi Das, Hai Dang Nguyen, Jian Yang, Samuel Sunday Ogunsola, Madeleine Hamilton, Yujia Wu, Ling Liu, Wenguang Cao, Chunyu Liu, Jiuyong Xie

The paper identifies cancer-specific exonic fragments by analyzing differentially expressed exons and somatic SNVs, revealing their association with tumor suppressor genes and potential for antigen discovery.

bioRxiv · Jun 25, 2025 · PreprintCancer Biology

Subtle stratification confounds estimates of heritability from rare variants

Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Hilary Finucane, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Sang Hong Lee, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, , Alkes L. Price

This study shows that subtle population stratification can confound heritability estimates from rare variants, even after standard corrections, suggesting the need for better stratification control in genetic studies.

bioRxiv · Apr 13, 2016 · PreprintGenetics