NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress- induced anhedonia and dendritic spine loss
Brandon W. Hughes, Benjamin M. Siemsen, Evgeny Tsvetkov, Stefano Berto, Jaswinder Kumar, Rebecca G Cornbrooks, Rose Marie Akiki, Jennifer Y. Cho, Jordan S. Carter, Kirsten K. Snyder, Ahlem Assali, Michael D. Scofield, Christopher W. Cowan, Makoto Taniguchi
This study shows that NPAS4 in the medial prefrontal cortex is required for chronic social defeat stress-induced anhedonia and dendritic spine loss, but not social avoidance or anxiety-like behavior.
eLife · Jan 30, 2023Peer-reviewedNeuroscience