Author

Michelle V. Wagner

Janssen Research & Development (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aaron A. ThompsoniD· 1 shared Anuli Anyanwu‐Ofili· 1 shared Daniel Riley· 1 shared David B. GoldsteiniD· 1 shared Gary TresaderniD· 1 shared Gunaretnam RajagopaliD· 1 shared Irina V. LebedevaiD· 1 shared Jay Wadia· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Aaron A. ThompsonORCID

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Author profile →

2 papers

Recent·Most cited

Structures of human Malic Enzyme 3

Tsehai A.J. Grell, Mark M. Mason, Aaron A. Thompson, José Carlos Gómez-Tamayo, Daniel Riley, Michelle V. Wagner, Ruth A. Steele, Rodrigo F. Ortiz‐Meoz, Jay Wadia, Paul L. Shaffer, Gary Tresadern, Sujata Sharma, Xiaodi Yu

This study determines the structures of human Malic Enzyme 3 (ME3) in various ligand binding states, revealing its tetrameric structure and dynamic Domain C, and provides insights into its non-allosteric nature and potential for drug development.

bioRxiv · Aug 25, 2022 · PreprintMolecular Biology

Precision genetic cellular models identify therapies protective against endoplasmic reticulum stress

Irina V. Lebedeva, Michelle V. Wagner, Sunil Sahdeo, Yifan Lu, Anuli Anyanwu‐Ofili, Matthew B. Harms, Jehangir S. Wadia, Gunaretnam Rajagopal, Michael J. Boland, David B. Goldstein

The paper identifies compounds that correct aberrant molecular phenotypes in cellular models of glycosylation defects using a phenotypic screening approach.

Cell Death and Disease · Aug 5, 2021Peer-reviewedNeuroscience