Author

Jeffrey Leonard

Nationwide Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Elaine R. MardisiD· 2 shared Adam P. OstendorfiD· 1 shared Adithe RivaldiiD· 1 shared Allison Daley· 1 shared Allison Thompson· 1 shared Ammar ShaikhouniiD· 1 shared Ari Zavarella· 1 shared Ashton S. HolubiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Elaine R. MardisORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Somatic variants activating the RAS-MAPK pathway confer susceptibility to hippocampal sclerosis in drug-resistant epilepsy

Lauren Mashburn‐Warren, Ashton S. Holub, Sahibjot Sran, Swetha Ramadesikan, Keaton Suh, Allison Thompson, James J. Anderson, Adithe Rivaldi, Ari Zavarella, Megan Chandler, Allison Daley, Corinne Strawser, Elizabeth A.R. Garfinkle, Jonathan Pindrik, Ammar Shaikhouni, , Tracy A. Bedrosian

The paper identifies somatic RAS-MAPK pathway activating variants in hippocampal sclerosis patients, linking them to seizure-induced injury and suggesting therapeutic targets.

bioRxiv · Apr 9, 2026 · PreprintNeuroscience

Samovar: Single-sample mosaic SNV calling with linked reads

Charlotte A. Darby, James Fitch, Patrick Joseph Brennan, Benjamin Kelly, Natalie Bir, Vincent J. Magrini, Jeffrey Leonard, Catherine E. Cottrell, Julie M. Gastier, Richard K. Wilson, Elaine R. Mardis, Peter White, Ben Langmead, Michael C. Schatz

Samovar calls mosaic SNVs in single samples using linked-read data with accuracy comparable to trio or tumor/normal pair analyses.

iScience · May 29, 2019Peer-reviewedGenomics