Endogenous insulin mediates dynamic coordination between pancreatic cancer and systemic metabolism
Jeffrey S.H. Lin, Aman A Mohammed, Keeley G. Hewton, Jingqiang Wang, Tiffany Z.Y Chen, Ivy S.Y Guo, Riley S.H Lam, Marcelo Ferraz Reinaldo, Vincent R. Richard, David F. Schaeffer, Daniel John Renouf, Christoph H. Borchers, Seth J. Parker, Josef Martin Penninger, James D. Johnson, Janel L. Kopp
This study shows that endogenous insulin in pancreatic cancer tumors affects tumor growth and systemic metabolism, with differential effects based on diet and mouse sex.
bioRxiv · Aug 27, 2026 · PreprintCancer Biology