Author

Jeffrey Zhou

Yale UniversityORCID 0000-0001-8293-7558Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jeffrey Zhou1 paper · University of Pennsylvania

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Junjie U. GuoiD· 2 shared Atagun U. IsiktasiD· 1 shared Austin M. VeireiD· 1 shared Aziz Eshov· 1 shared Denethi WijegunawardanaiD· 1 shared João D. PereiraiD· 1 shared Juliana M. S. Salgado· 1 shared Manasi AgrawaliD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Junjie U. GuoORCID

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2 papers

Recent·Most cited

NeuroscienceNature NeurosciencePeer-reviewedAug 11, 2025

Aberrant splicing exonizes C9ORF72 repeat expansion in ALS/FTD

Suzhou Yang, Denethi Wijegunawardana, Udit Sheth…·Junjie U. Guo

The paper shows that C9ORF72 repeat expansions cause aberrant splicing, leading to exonization and altered RNA processing in ALS/FTD.

16 citationstop 1%

humanbulk RNA-seq

Molecular BiologyNature CommunicationsPeer-reviewedJul 3, 2020

C9orf72 dipeptide repeats inhibit UPF1-mediated RNA decay independent of stress granule formation

Yu Sun, Aziz Eshov, Jeffrey Zhou…·Junjie U. Guo

This study shows that C9orf72 dipeptide repeats inhibit UPF1-mediated RNA decay without requiring stress granule formation, contributing to RNA accumulation in c9ALS/FTD.

57 citationstop 4%

humanexperimental assay