Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans
Mostofa Rafid Uddin, Zhiqian Zheng, Kashish Gandhi, Hung‐Ching Chang, Jenesis Kozel, Yaswanth Gali, Silas A. Buck, Jill R. Glausier, George C. Tseng, Zachary Freyberg, Min Xu
The paper develops a computational pipeline to link nuclear morphology to mRNA expression in neurons across aging in mice and humans, revealing subtype-specific morphology differences and age-related interactions.
bioRxiv · Oct 16, 2025 · PreprintBioinformatics