Jill R. Glausier

The paper introduces SPInfer, a workflow for spatial proteomic inference that improves cell segmentation in human brain tissue, enabling better biological discovery at population scale.

This study identifies tissue-specific molecular signatures and convergent pathways in suicide by analyzing transcriptomic data from blood and brain tissues.

This study examines RNA expression in thalamic nuclei of OCD patients and controls, finding minimal differential expression despite previous findings in other brain regions.

The paper develops a computational pipeline to link nuclear morphology to mRNA expression in neurons across aging in mice and humans, revealing subtype-specific morphology differences and age-related interactions.

This paper uses volume electron microscopy to analyze 3D synaptic structures in postmortem human prefrontal cortex, showing consistency with experimental models and revealing complex synaptic features.

The paper identifies circRNA hypomethylation in the human amygdala linked to FKBP5 in alcohol use disorder, with replication in an animal model.

This paper introduces SISTM to map 3D synaptic nanoarchitecture in brain tissue across species using cryo-ET and STA, revealing conserved structural features in human postmortem tissue.

The paper shows aging reduces mRNA expression of dopamine and glutamate markers in midbrain neurons of mice and humans, but not protein levels or cell numbers.

The paper identifies Ribosome-Associated Vesicles (RAVs) as dynamic platforms that facilitate activity-dependent local translation in neurons by transporting ribosomes to distal processes.

The paper uses single nuclei RNA-sequencing to identify striatal cell types in humans and rhesus macaques and finds molecular changes linked to opioid use disorder.

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

The paper introduces a cryo-FIB workflow to image brain tissue via in situ cryo-EM, enabling visualization of subcellular structures in fresh, unfixed mouse and postmortem human brain tissue.

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

The paper shows that mitochondrial proteostasis genes in a neurodevelopmental syndrome locus are essential for synapse function and behavior in Drosophila.

This study identifies transcriptional changes in opioid use disorder brains, linking neuroinflammation and synaptic remodeling through RNA-seq and integrative analyses.

The paper identifies VGLUT expression as a sex-dependent mediator of age-related dopamine neuron vulnerability in Parkinson's disease.

This study shows that postsynaptic serine racemase regulates NMDA receptor function in mouse hippocampal neurons, with age-dependent effects on long-term potentiation and GluN2B expression.

This study identifies synaptic proteome alterations in the primary auditory cortex of schizophrenia patients, showing coordinated changes in postsynaptic proteins not explained by global protein levels or confounding factors.

The paper identifies a mitochondrial transporter interactome disruption in 22q11.2 syndrome, linking it to synapse function and behavior.