Min Xu

Localization of Macromolecules in Crowded Cellular Cryo-electron Tomograms from Extremely Sparse Labels

TomoPicker is a macromolecule localization method for cryo-ET tomograms that achieves comparable performance to supervised methods with significantly fewer annotations.

Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans

The paper develops a computational pipeline to link nuclear morphology to mRNA expression in neurons across aging in mice and humans, revealing subtype-specific morphology differences and age-related interactions.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Unsupervised Multi-scale Segmentation of Cellular Cryo-electron Tomograms with Stable Diffusion Foundation Model

The paper introduces an unsupervised method for segmenting subcellular structures in cryo-ET images using a Stable Diffusion model, achieving performance close to expert annotations.

Deep Video Analysis for Bacteria Genotype Prediction

This paper uses video analysis to predict bacterial genotypes from spatiotemporal growth patterns, showing that low-resolution microscopy videos can classify genetic modifications in Vibrio cholerae.

DUAL: deep unsupervised simultaneous simulation and denoising for cryo-electron tomography

DUAL improves cryo-electron tomography by simultaneously denoising and simulating data without labeled training data, enhancing structural detection and annotation.

DISCA: high-throughput cryo-ET structural pattern mining by deep unsupervised clustering

DISCA uses deep learning to automatically cluster cryo-ET data into homogeneous structural subsets without templates or labels.

SCAN-ATAC Sim: a scalable and efficient method for simulating single-cell ATAC-seq from bulk-tissue experiments

SCAN-ATAC-Sim simulates scATAC-seq data from bulk ATAC-seq to benchmark analysis methods with known cell-type labels.