Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models
R Chin, Rishi Rakhit, Dara Ditsworth, Chengzhong Wang, Johan Bartholoméüs, Song Liu, Akash Mody, Alex Laishu, Andrea Eastes, Chao Tai, Roy Y. Kim, Jessica Li, Steven Hansberry, Saurabh Khasnavis, Victoria A. Rafalski, , Nicholas T. Hertz
This study identifies MTK458, a PINK1 activator, which reduces α-synuclein pathology and pUb levels in Parkinson's disease models and correlates plasma pUb with disease progression.
bioRxiv · Feb 14, 2023 · PreprintNeuroscience