This study identifies MTK458, a PINK1 activator, which reduces α-synuclein pathology and pUb levels in Parkinson's disease models and correlates plasma pUb with disease progression.

bioRxiv · Feb 14, 2023 · PreprintNeuroscience

Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19

Michael T. Y. Lam, Sascha H. C. Duttke, Mazen Faris Odish, Hiep Dinh Le, Emily A. Hansen, Celina T. Nguyen, Samantha Trescott, Roy Y. Kim, Shaunak Deota, Max W. Chang, Arjun Patel, Mark Hepokoski, Mona Alotaibi, Mark L. Rolfsen, Katherine Perofsky, , Nicole G. Coufal

The paper profiles the active cistrome in peripheral leukocytes of critically ill COVID-19 patients to identify severity-associated cis-regulatory elements and their regulatory programs.

Cell Reports Medicine · Jan 25, 2023Peer-reviewedGenomics

Gene regulatory networks underlying human microglia maturation

Claudia Z. Han, Rick Z. Li, Emily A. Hansen, Hunter R. Bennett, Olivier Poirion, Justin Buchanan, Jean F. Challacombe, Bethany R. Fixsen, Samantha Trescott, Johannes C. M. Schlachetzki, Sebastian Preißl, Allen Wang, Carolyn O’Connor, Anna S. Warden, Shreya Shriram, , Nicole G. Coufal

This study defines age-specific brain environmental factors driving microglia phenotypes through transcriptomic and epigenomic analysis of human fetal and postnatal microglia.

bioRxiv · Jun 2, 2021 · PreprintGenomics