Environmental Contributions to Proton Sharing in Protein Low-Barrier Hydrogen Bonds
Jiusheng Lin, Oksana O. Gerlits, Daniel W. Kneller, Kevin L. Weiss, Leighton Coates, Jennifer L. Clarke, Mark A. Hix, Solomon Yamoah Effah, Andrey Y. Kovalevsky, Alice R. Walker, Mark A. Wilson
This study uses neutron crystallography and simulations to analyze proton sharing in low-barrier hydrogen bonds in DJ-1 and YajL, showing how mutations affect proton delocalization and mobility.
Biochemistry · Feb 9, 2026Peer-reviewedBiochemistry