Author

Kevin L. Weiss

Oak Ridge National LaboratoryORCID 0000-0002-6486-8007Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Organism:human· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Leighton CoatesiD· 2 shared Alice R. WalkeriD· 1 shared Amarnath NatarajaniD· 1 shared Andrey Y. KovalevskyiD· 1 shared Anne MarteliD· 1 shared Aya OkudaiD· 1 shared Brian Washburn· 1 shared Cheryl Pye· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

Leighton CoatesORCID

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Author profile →

4 papers

Recent·Most cited

Critical amino acid residues in the N-terminal domain of NADPH-dependent assimilatory sulfite reductase flavoprotein mediate octameric assembly

Nidhi Walia, Thaís de Almeida Pedrete, Fozieh Ahmadizadeh, Ekhtiar Rahman, Yashika Garg, Brian Washburn, Cheryl Pye, Fanny C. Liu, Peter S. Randolph, Kevin L. Weiss, Gergely Nagy, Christian Bleiholder, M. Elizabeth Stroupe

The paper identifies critical amino acid residues in the N-terminal domain of SiRFP that mediate octameric assembly, revealing their role in stabilizing the enzyme's structure.

Protein Science · Jul 11, 2026Peer-reviewedBiophysics

Integrating Segmental Deuteration iCM-SANS with SAXS and MD for Dynamical Analysis of Multi-domain Proteins

Aya Okuda, Rintaro Inoue, Minami Kurokawa, Anne Martel, Lionel Porcar, Rikuto Osaki, Kaori Fukuzawa, Kevin L. Weiss, Sai Venkatesh Pingali, Reiko Urade, Masaaki Sugiyama

The paper develops a protocol combining segmental deuteration and multi-step protein ligation with SAXS and iCM-SANS to improve discrimination of conformational ensembles in multi-domain proteins.

bioRxiv · Feb 27, 2026 · PreprintBiophysics

Environmental Contributions to Proton Sharing in Protein Low-Barrier Hydrogen Bonds

Jiusheng Lin, Oksana O. Gerlits, Daniel W. Kneller, Kevin L. Weiss, Leighton Coates, Jennifer L. Clarke, Mark A. Hix, Solomon Yamoah Effah, Andrey Y. Kovalevsky, Alice R. Walker, Mark A. Wilson

This study uses neutron crystallography and simulations to analyze proton sharing in low-barrier hydrogen bonds in DJ-1 and YajL, showing how mutations affect proton delocalization and mobility.

Biochemistry · Feb 9, 2026Peer-reviewedBiochemistry

The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase

Jahaun Azadmanesh, Katelyn Slobodnik, Lucas R. Struble, Jeffrey J. Lovelace, Erika A. Cone, Medhanjali Dasgupta, William E. Lutz, Siddhartha Kumar, Amarnath Natarajan, Leighton Coates, Kevin L. Weiss, Dean A. A. Myles, Thomas Kröll, Gloria E. O. Borgstahl

This study investigates the role of Tyr34 in MnSOD catalysis using neutron diffraction, X-ray spectroscopy, and quantum chemistry calculations, revealing its impact on proton-coupled electron transfer.

Nature Communications · Feb 22, 2025Peer-reviewedBiochemistry