Conventional dendritic cells type I with an enhanced type-I-IFN signaling underpin anti-tumor immune responses in brain metastases
Fiona James, Alena Revalová, Christopher M. Fife, Jennifer Williams, Dario Guglietta, Zarnaz Hadi, Elton J. R. Vasconcelos, Ashley Sunderland, Grace Mallett, Nicola Ingram, Tsuneyasu Kaisho, William J. Brackenbury, Merin Lawrence, David R. Westhead, Andrew S. MacDonald, Mihaela Lorger
This study identifies conventional dendritic cells type 1 (cDC1s) as critical for anti-tumor immunity in brain metastases, showing their unique role in promoting CD8+ T cell responses and enhancing immunotherapy efficacy.
bioRxiv · Jul 8, 2026 · PreprintCancer Biology