Author

Mihaela Lorger

University of LeedsORCID 0000-0002-2943-2152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Alena Revalová· 1 shared Andrew S. MacDonaldiD· 1 shared Ashley Sunderland· 1 shared Christopher M. FifeiD· 1 shared Dario Guglietta· 1 shared David R. WestheadiD· 1 shared Elton J. R. VasconcelosiD· 1 shared Fiona JamesiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

Alena Revalová

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Conventional dendritic cells type I with an enhanced type-I-IFN signaling underpin anti-tumor immune responses in brain metastases

Fiona James, Alena Revalová, Christopher M. Fife, Jennifer Williams, Dario Guglietta, Zarnaz Hadi, Elton J. R. Vasconcelos, Ashley Sunderland, Grace Mallett, Nicola Ingram, Tsuneyasu Kaisho, William J. Brackenbury, Merin Lawrence, David R. Westhead, Andrew S. MacDonald, Mihaela Lorger

This study identifies conventional dendritic cells type 1 (cDC1s) as critical for anti-tumor immunity in brain metastases, showing their unique role in promoting CD8+ T cell responses and enhancing immunotherapy efficacy.

bioRxiv · Jul 8, 2026 · PreprintCancer Biology

Asparagine availability differentially regulates early vs late CD4+ and CD8+ T cell activation, metabolism and autophagy

Mingcheng Song, Linda V. Sinclair, Mary J. Tozer, Mihaela Lorger, Robert J. Salmond

This study shows CD4+ T cells rely more on asparagine uptake than CD8+ T cells for activation, differentiation, metabolism, and autophagy, with CD8+ cells expressing more ASNS.

bioRxiv · Apr 29, 2026 · PreprintImmunology