Numb reduces Tau levels and prevents neurodegeneration in mouse models of tauopathy in an isoform-specific manner
Marine Lacomme, Sarah C. Hales, Thomas W. Brown, Katarina Stevanovic, Christine Jolicoeur, Jenny Cai, Thérence Bois, Mélissa Desrosiers, Deniz Dalkara, Michel Cayouette
This study shows that Numb regulates Tau levels and prevents neurodegeneration in tauopathy models, with Numb-72 specifically reducing intracellular Tau.
Science Advances · Oct 19, 2022Peer-reviewedNeuroscience