Michel Cayouette

This study identifies Foxp1 as a transcriptional regulator that coordinates early progenitor identity with neurogenic progression in the developing retina by activating early-stage genes and proneural factors while repressing late temporal factors.

The paper describes a revised model of the subretinal space architecture in fish and mouse, showing that Muller glia and RPE interact with cone outer segments through extended apical processes.

This study identifies cadherin 4 as a key molecule for layer-specific targeting of retinal ganglion cells in sublaminae 1 and 3a, affecting their connectivity and visual responses.

This study shows Pten and Dscam regulate amacrine cell spacing through endocytic trafficking of cell adhesion and signaling molecules, with altered extracellular vesicles and Wnt signaling in Pten mutants.

This study identifies Pou3f1 as a master regulator of contralateral retinogeniculate projections by controlling a gene regulatory network in developing mouse retinal ganglion cells.

This study shows that temporal identity factors can reprogram adult Muller glial cells and fibroblasts into neurons in mice, using scRNA-seq to validate the transcriptional changes.

This study shows Ikzf1 and Ikzf4 regulate distinct cell fates in the mouse retina through different cis-regulatory elements and temporal expression patterns.

This study shows that Numb regulates Tau levels and prevents neurodegeneration in tauopathy models, with Numb-72 specifically reducing intracellular Tau.

This study shows that Atoh7 is essential for RGC survival but not for their specification, as RGCs can develop without Atoh7 when apoptosis is inhibited.

This study identifies Casz1's role in regulating temporal identity transitions in neural progenitors through interactions with the NuRD and polycomb repressor complexes during retinal neurogenesis.