Epigenetic derepression of H3K9me3 mitigates Alzheimer-related pathology and improves cognition via immunomodulation and Vgf induction
Dieu-Trang S. Fuchs, Jean‐Philippe Vit, Altan Rentsendorj, Julia Sheyn, Haoshen Shi, Yosef Koronyo, Oksana M. Chepurna, Miyah R. Davis, Jered W. Wilson, Lon S. S. Schneider, Stuart L. Graham, Vivek Gupta, Margaret L. Fahnestock, Tao Sun, Michael T. Kleinman, , Maya Koronyo‐Hamaoui
This study shows that inhibiting H3K9me3 with ETP69 reduces AD pathology and improves cognition by modulating neuroinflammation and inducing Vgf.
bioRxiv · Oct 15, 2024 · PreprintNeuroscience