Stuart L. Graham

The paper identifies UCHL1 dysregulation and synaptic loss in the retina as markers of Alzheimer's disease severity using integrated multi-omics analysis.

This paper develops a polygenic risk score for glaucoma with improved performance across major ancestries, enabling earlier detection and targeted treatment of high-risk individuals.

The paper identifies Chlamydia pneumoniae infection and NLRP3 inflammasome activation in Alzheimer's disease retinas, linking them to disease progression and cognitive impairment.

This study shows that inhibiting H3K9me3 with ETP69 reduces AD pathology and improves cognition by modulating neuroinflammation and inducing Vgf.

This study uses iPSC-derived retinal organoids to identify retinal ganglion cell-specific expression quantitative trait loci associated with primary open-angle glaucoma.

This study compares proteomic changes in a rat glaucoma model with human glaucoma, identifying shared and distinct molecular features related to oxidative stress, mitochondrial dysfunction, and immune pathways.