The paper identifies sex-specific molecular and pathological differences in the retina-brain axis of Alzheimer's disease, linking estrogen receptor imbalance to female vulnerability.

bioRxiv · May 5, 2026 · PreprintNeuroscience

Synergistic retinal UCHL1 dysregulation and synaptic vulnerability reflect Alzheimer's disease severity

Altan Rentsendorj, Jean‐Philippe Vit, A. Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barrón, Anthony Rodriguez, Bhakta Prasad Gaire, Ousman Jallow, Julia Sheyn, Miyah R. Davis, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, , Maya Koronyo‐Hamaoui

The paper identifies UCHL1 dysregulation and synaptic loss in the retina as markers of Alzheimer's disease severity using integrated multi-omics analysis.

bioRxiv · Feb 5, 2026 · PreprintNeuroscience

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina

Bhakta Prasad Gaire, Yosef Koronyo, Jean‐Philippe Vit, A. Hutton, Lalita Subedi, Dieu-Trang S. Fuchs, Natalie Swerdlow, Altan Rentsendorj, Saba Shahin, Daisy Martinon, Edward Robinson, Alexander V. Ljubimov, Julie A. Schneider, Lon S. Schneider, Debra Hawes, , Maya Koronyo‐Hamaoui

The paper identifies Chlamydia pneumoniae infection and NLRP3 inflammasome activation in Alzheimer's disease retinas, linking them to disease progression and cognitive impairment.

Nature Communications · Jan 22, 2026Peer-reviewedNeuroscience

Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer's disease

Miyah R. Davis, Edward Robinson, Yosef Koronyo, Elena Salobrar‐García, Altan Rentsendorj, Bhakta Prasad Gaire, Nazanin Mirzaei, Rakez Kayed, Alfredo A. Sadun, Alexander V. Ljubimov, Lon S. S. Schneider, Debra Hawes, Keith L. Black, Dieu-Trang S. Fuchs, Maya Koronyo‐Hamaoui

This study shows that pathological tau isoforms in retinal ganglion cells (RGCs) are linked to RGC degeneration in Alzheimer's disease, with significant correlations between tau levels and disease severity.

Acta Neuropathologica Communications · Feb 15, 2025Peer-reviewedPathology

Epigenetic derepression of H3K9me3 mitigates Alzheimer-related pathology and improves cognition via immunomodulation and Vgf induction

Dieu-Trang S. Fuchs, Jean‐Philippe Vit, Altan Rentsendorj, Julia Sheyn, Haoshen Shi, Yosef Koronyo, Oksana M. Chepurna, Miyah R. Davis, Jered W. Wilson, Lon S. S. Schneider, Stuart L. Graham, Vivek Gupta, Margaret L. Fahnestock, Tao Sun, Michael T. Kleinman, , Maya Koronyo‐Hamaoui

This study shows that inhibiting H3K9me3 with ETP69 reduces AD pathology and improves cognition by modulating neuroinflammation and inducing Vgf.

bioRxiv · Oct 15, 2024 · PreprintNeuroscience

Age-related memory CD8 T cells induce and track Alzheimers-like neurodegeneration

Akanksha Panwar, Altan Rentsendorj, Michelle Jhun, Robert M. Cohen, Ryan Cordner, Nicole Gull, Robert N. Pechnick, Gretchen Duvall, Armen Mardiros, David Golchian, Hannah E. Schubloom, Lee‐Way Jin, Debby Van Dam, Yannick Vermeiren, Hans De Reu, , Christopher J. Wheeler

This paper shows that age-related memory CD8 T cells drive AD-like neurodegeneration upstream of Aβ/pTau in mice and are elevated in human AD patients.

Proceedings of the National Academy of Sciences · Jul 12, 2024Peer-reviewedNeuroscience

Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status

Haoshen Shi, Nazanin Mirzaei, Yosef Koronyo, Miyah R. Davis, Edward Robinson, Gila M. Braun, Ousman Jallow, Altan Rentsendorj, V. Krishnan Ramanujan, Justyna Fert‐Bober, Andrei A. Kramerov, Alexander V. Ljubimov, Lon S. Schneider, Warren G. Tourtellotte, Debra Hawes, , Maya Koronyo‐Hamaoui

This study quantifies retinal tau isoforms in early and advanced AD and links them to brain pathology and cognitive status.

Acta Neuropathologica · Jul 9, 2024Peer-reviewedPathology

Distinctive retinal peri-arteriolar versus peri-venular amyloid plaque distribution correlates with the cognitive performance

Oana M. Dumitrascu, Jonah Doustar, Dieu-Trang S. Fuchs, Yosef Koronyo, Dale S. Sherman, Michelle Shizu Miller, K. O. Johnson, Roxana Octavia Carare, Steven R. Verdooner, Patrick D. Lyden, Julie A. Schneider, Keith L. Black, Maya Koronyo‐Hamaoui

The paper quantifies retinal perivascular amyloid plaque distribution in relation to cognitive performance, finding higher peri-arteriolar amyloid burden and correlations with cognitive decline.

Acta Neuropathologica Communications · Jun 28, 2024Peer-reviewedPathology

Nano immunoconjugates crossing blood-brain barrier activate local brain tumor immune system for glioma treatment

Anna Galstyan, Antonella Chiechi, Alan J. Korman, Tao Sun, Liron L. Israel, Oliver Braubach, Rameshwar Patil, Ekaterina Shatalova, Vladimir A. Ljubimov, Janet Markman, Zachary Grodzinski, Keith L. Black, Manuel L. Penichet, Eggehard Holler, Alexander V. Ljubimov, , Julia Y. Ljubimova

This study develops nano immunoconjugates that cross the blood-brain barrier to activate local immune responses against gliomas, improving survival in treated mice.

bioRxiv · Nov 9, 2018 · PreprintImmunology