Specific activation of HIV-1 from monocytic reservoir cells by bromodomain inhibitor in humanized mice in vivo
Guangming Li, Zheng Zhang, Natalia Reszka-Blanco, Feng Li, Liqun Chi, Jianping Ma, Jerry Jeffrey, Liang Cheng, Lishan Su
This study shows that the bromodomain inhibitor I-BET151 activates HIV-1 transcription in monocytic cells but not CD4+ T cells under cART in humanized mice.
bioRxiv · Jul 24, 2018 · PreprintImmunology