ImmunologybioRxivPreprint
Harnessing the PRDM1-PGC1A axis to enhance CAR T cell efficacy
Sidney YY Wang, Xiufen Chen, Xubin Li…·Jutin Kline
This study identifies the PRDM1-PGC1A axis as a key regulator of CAR T cell function, showing that inhibiting PRDM1 or activating PGC1A improves CAR T cell efficacy in multiple tumor models.
DOI 10.64898/2026.10.15.759372