Author

Xiufen Chen

University of ChicagoORCID 0009-0006-6895-2819Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Alan B CooperiD· 2 shared Justin Paul KlineiD· 2 shared Lishi XieiD· 2 shared Alexander BagaeviD· 1 shared Ali ElSheikh· 1 shared Ash A. AlizadehiD· 1 shared Benedikt W. PelzeriD· 1 shared Brendan W. MacNabbiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersImmunology

Alan B CooperORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 21, 2026

Harnessing the PRDM1-PGC1A axis to enhance CAR T cell efficacy

Sidney YY Wang, Xiufen Chen, Xubin Li…·Jutin Kline

This study identifies the PRDM1-PGC1A axis as a key regulator of CAR T cell function, showing that inhibiting PRDM1 or activating PGC1A improves CAR T cell efficacy in multiple tumor models.

DOI 10.64898/2026.10.15.759372

humanstatistical model

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ImmunologyCancer Immunology ResearchPeer-reviewedMay 8, 2026

Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

Erting Tang, Yifei Hu, Guoshuai Cao…·Jun Huang

This study shows that low-strength type I interferon signaling enhances CAR T-cell efficacy against B-cell lymphoma and leukemia without causing in vivo toxicity.

3 citations

humanbulk RNA-seq

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Cancer BiologyBloodPeer-reviewedJan 27, 2025

Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma

Sravya Tumuluru, James K. Godfrey, Alan B Cooper…·Justin Paul Kline

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

35 citationstop 1%

humanbulk RNA-seq

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