IRG1/itaconate/NRF2/GSH axis in tumor-associated macrophages drives therapy resistance and immune evasion in BRCA1-deficient breast cancer
Yabing Nan, Sophie O'Keefe, Xiadi He, Qingyu Luo, Xiaowei Wu, Jing Ni, Yutian Zou, Jerryd Marcus Meade, Yutong Li, Renlei Ji, Anwaruddin Mohammad, Pankaj Kumar, Qiwei Wang, Jean J. Zhao
This study identifies the IRG1/itaconate/NRF2/GSH axis in TAMs as a driver of PARPi resistance and immune evasion in BRCA1-deficient breast cancer, with pharmacological inhibition showing therapeutic potential.
bioRxiv · Oct 14, 2025 · PreprintCancer Biology