Cancer BiologybioRxivPreprint
IRG1/itaconate/NRF2/GSH axis in tumor-associated macrophages drives therapy resistance and immune evasion in BRCA1-deficient breast cancer
Yabing Nan, Sophie O'Keefe, Xiadi He…·Jean J. Zhao
This study identifies the IRG1/itaconate/NRF2/GSH axis in TAMs as a driver of PARPi resistance and immune evasion in BRCA1-deficient breast cancer, with pharmacological inhibition showing therapeutic potential.
DOI 10.1101/2025.10.14.682312