Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins
Galen C. Rask, Cenny Taslim, Ariunaa Bayanjargal, Matthew V. Cannon, Julia Selich‐Anderson, Jesse C. Crow, Aundrietta D. Duncan, Emily R. Theisen
This study shows seclidemstat inhibits the transcriptional activity of multiple FET fusion oncoproteins in vitro, suggesting it as a promising treatment for FET-rearranged sarcomas.
bioRxiv · May 19, 2024 · PreprintCancer Biology