RNA-SeqEZPZ is a user-friendly pipeline for RNA-Seq analysis with interactive visualizations, offering both point-and-click and command-line interfaces for reproducible and customizable transcriptomics workflows.

GigaScience · Nov 12, 2025Peer-reviewedGenomics

N'-(1-phenylethylidene)-benzohydrazide cytotoxicity is LSD1 independent and linked to Fe-S cluster disruption in Ewing sarcoma

John William Sherman, Galen C. Rask, Bingcong Xiong, E. John Tokarsky, Aundrietta D. Duncan, Eranthie Weerapana, Emily R. Theisen

This paper identifies that SP-2509 and SP-2577, LSD1 inhibitors, induce cell death in Ewing sarcoma through Fe-S cluster disruption, independent of LSD1 inhibition.

bioRxiv · Jun 20, 2025 · PreprintPharmacology & Toxicology

Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins

Galen C. Rask, Cenny Taslim, Ariunaa Bayanjargal, Matthew V. Cannon, Julia Selich‐Anderson, Jesse C. Crow, Aundrietta D. Duncan, Emily R. Theisen

This study shows seclidemstat inhibits the transcriptional activity of multiple FET fusion oncoproteins in vitro, suggesting it as a promising treatment for FET-rearranged sarcomas.

bioRxiv · May 19, 2024 · PreprintCancer Biology

Selective Modulator of Nuclear Receptor PPARy with Reduced Adipogenic Potential Ameliorates Experimental Nephrotic Syndrome

Claire Bryant, Galen C. Rask, Amanda P. Waller, Amy Webb, Marina Galdino da Rocha Pitta, Angélica Amorim Amato, Rachel E. Cianciolo, Rajgopal Govindarajan, Brian Becknell, Bryce A. Kerlin, Francisco de Assis Rocha Neves, Alessia Fornoni, Shipra Agrawal

This study compares the effects of GQ-16, a PPARγ partial agonist, and pioglitazone, a PPARγ full agonist, in treating nephrotic syndrome in rats, finding that GQ-16 reduces proteinuria and co-morbidities with fewer adipogenic side effects.

iScience · Feb 28, 2022Peer-reviewedMolecular Biology