Matthew V. Cannon

Integrative Single-cell and Spatial Transcriptomic Analysis of Osteosarcoma Reveals Conserved and Distinct Ecosystems Across Sites and Species

This study integrates single-cell and spatial transcriptomic data across species to identify conserved and distinct tumor ecosystems in osteosarcoma, revealing canine models as more faithful and highlighting ECM signaling in metastatic lesions.

SCANBIT facilitates identification of tumor cell populations in scRNAseq data using pseudobulked SNV calls

SCANBIT identifies tumor cell populations in scRNA-seq data by using pseudobulked SNV calls, showing that mutational burden affects identification accuracy.

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins

This study shows seclidemstat inhibits the transcriptional activity of multiple FET fusion oncoproteins in vitro, suggesting it as a promising treatment for FET-rearranged sarcomas.

Zebrafish her3 knockout impacts developmental and cancer-related gene signatures

This study generates and characterizes a zebrafish her3/HES3 knockout to examine its role in neural development and cancer-related pathways.