Interferon receptor gene dosage determines multiple hallmarks of Down syndrome
Katherine A. Waugh, Ross Minter, Jessica A Baxter, Congwu Chi, Kathryn D. Tuttle, Neetha Paul Eduthan, Matthew D. Galbraith, Kohl T. Kinning, Zdeněk Andrysík, Paula Araya, Hannah Dougherty, Lauren N. Dunn, Michael P. Ludwig, Kyndal A. Schade, Dayna Tracy, , Joaquin Maximiliano Espinosa
The paper shows that correcting interferon receptor gene dosage in a mouse model of trisomy 21 rescues multiple key phenotypes associated with Down syndrome.
bioRxiv · Feb 3, 2022 · PreprintGenetics